June Meeting Notice

Tuesday, June 5, 2007

Chiral Bonded Phases- Choosing RPLC, NPLC or SFC?

Dr. Richard A. Henry

The Pennsylvania State University

Abstract:

Excellent enantiomer separations can be accomplished under normal phase or reversed phase HPLC conditions using modern bonded chiral stationary phases (CSPs). Some packed columns even work well in both modes. Separation mechanisms are often described in terms of stationary phase 3-D cavities that snugly fit certain molecules and provide different complexation energies for left-handed and right-handed isomers. Since polar functional groups are required in order for a bonded phase to interact effectively in this manner, normal phase HPLC, where polar interaction controls retention, has remained more popular than other types of HPLC such as reversed-phase or ion-exchange. This talk will review recent developments in bonded CSPs, including Cyclodextrins, Macrocyclic Gycopeptides, and Polycyclic Amines, and compare results under reversed-phase and normal-phase operating conditions. SFC experiments with high fluidity mobile phases using the same columns will also be described and compared. Some unique advantages of SFC for both chiral and achiral separations will be discussed and weighed against the disadvantages.

About the Speaker:

Dr. Richard A. Henry received his B.S. degree in Chemistry from Juniata College, Huntingdon, PA and Ph.D. in Analytical Chemistry from Penn State University, University Park, PA. After a teaching appointment and postdoctoral position in separations with Professor L. B. Rogers at Purdue University, he joined DuPont at the Experimental Station in Wilmington, DE in 1967, where he worked at Caruthers Lab and Central Research before becoming one of the first employees of the Analytical Instrument Products Division. Dick worked closely with Dr. Jack Kirkland in the development of novel LC packing materials. After building a strong LC applications group at DuPont Instruments, Dick joined Spectra-Physics in the San Francisco Bay Area, where he helped establish their presence in the HPLC Market. In 1985, he founded Keystone Scientific, Inc., in Bellefonte, PA to serve the column needs of the analytical HPLC community with a particular emphasis on reduced-bore technology. The Keystone philosophy was unique at the time in that the company supported a sophisticated machine shop that manufactured many of its own parts to prepare custom and novel LC column designs. In addition to LC hardware and columns, Keystone also manufactured special LC bonded phases that imparted extra selectivity for different analytical applications. Dick retired from Keystone in 2002 after it was sold to Thermo Corporation. Dick was also Professor of Analytical Chemistry (retired emeritus) and Director of Analytical Laboratories at Penn State University in University Park, PA from 1985-2001, and taught a two-semester Instrumental Analysis Course to chemistry majors. He is currently active as a consultant in liquid phase separations and can be reached at rhenry@psualum.com.

Details:

Location:	D'ignazio's Towne House
Times:	5:00 PM Executive Committee Meeting 5:45 PM Social "Hour" 6:30 PM Dinner 7:30 PM Presentation
Cost:	$30
Dinner Choices:	Chicken Breast Baked Salmon Eggplant Parmesan with Marinara Sauce

NOTICE TO STUDENTS AND FACULTY: Full-time students with valid ID may attend dinner meetings at half-price. Faculty members at colleges and universities are urged to bring one or more students to the meeting. If they do, they also can attend at half-price.