February Meeting Notice

Tuesday, February 22, 2011

Clint Amoss: Chiral Separations

Clint Amoss

Chiral Technologies

Abstract:

The question of: Which chiral stationary phase (CSP) do I need to achieve enantioseparation of a given racemic mixture? is the question most frequently posed to experts in the field of chromatographic enanatiomer separation. Given the numerous chiral stationary phases reported to date (ca. 2000 reported in the literature, with more than 300 of them being commercially available), the answer to this fundamental question is nontrivial. In fact, with rare exceptions it is essentially impossible to predict a priori suitable mobile phase/column combinations for a given chiral compound, even when sophisticated structure-based molecular modeling tools are employed. Fortunately, polysaccharide-based phases have emerged as universal tools for chromatographic enantiomer separation. This family of CSPs displays exceptionally broad chiral recognition capabilities in numerous chromatographic modes, covering reversed phase, polar organic, supercritical fluid and apolar mobile phase environments. Expedient identification of “ideal” enantiomer separation conditions for a given problem can be achieved via low-sophistication screening strategies.
In this talk an overview will be provided on recent trends in chiral method development using polysaccharide-based CSPs, covering both analytical and preparative applications in drug development, food and flavor industry, environmental monitoring, and material sciences. Special attention will be given to high throughput screening protocols, capable of establishing promising enantiomer separation conditions in a matter of a few hours. In this context, particular emphasis will be placed on globally solvent-tolerant immobilized polysaccharide-based CSPs, exploiting the benefits of a largely extended range of mobile phase systems. Finally, the important role of polysaccharide-based CSPs for continuous process-scale enantiomer separation will be discussed as a “green” alternative to established, often waste-intensive asymmetric synthesis protocols.

About the Speaker:

Clint Amoss received his Bachelor’s degree from Juniata College and his Ph.D. in Analytical Chemistry from Duke University under the direction of Prof. C.H. Lochmüller. Clint started his professional career by performing HPLC for three years at Phillips Petroleum Company in Bartlesville, OK, at a time when HPLC was emerging as a major analytical technique. He then returned to his native Delaware Valley to perform GC, HPLC and GPC, as well as 2-dimensional LC/GPC first for ARCO Chemical Company and then for Lyondell Chemical Company, when ARCO Chemical was acquired by Lyondell. Clint maintained a similar position with Bayer Corporation when Lyondell sold its polyether polyols business to Bayer in 2000. Since 2002 Clint has been employed as a Senior Chemist, Laboratory Products for Chiral Technologies, West Chester, PA, where he dispenses technical advice to customers, develops chiral separation methods, and develops applications for new products. Clint is a former secretary, program chairman, and president of the CFDV, as well as former chairman of the CFDV Introductory LC short Course and is currently chairman of the CFDV Publicity Committee. Clint has recently contributed a comprehensive review on separation of chiral compounds on polysaccharide-based columns to the book “Chiral Separation Methods for Pharmaceutical and Biotechnical Products”, edited by Satinder Ahuja (Wiley, 2011).

Details:

Location:	D'ignazio's Towne House
Times:	5:00 PM Executive Committee Meeting 5:45 PM Social "Hour" 6:30 PM Dinner 7:30 PM Presentation
Cost:	$30
Dinner Choices:	Flounder w/crab meat Chicken Marsala Grilled Vegetable Cannelloni

NOTICE TO STUDENTS AND FACULTY: Full-time students with valid ID may attend dinner meetings at half-price. Faculty members at colleges and universities are urged to bring one or more students to the meeting. If they do, they also can attend at half-price.