Printable Meeting FlierOctober Meeting Notice
Tuesday, October 12, 2010
Gas Chromatography - It's Just Better
Prof. Frank David
Research Institute for Chromatography, Pres. Kennedypark 26, 8500 Kortrijk Belgium and Pfizer Analytical Research Center (PARC), Ghent University, Krijgslaan 281 S4, 9000 Gent, Belgium
Abstract:
During the 1980s and 1990s, capillary gas chromatography (CGC) evolved into a mature analytical separation technique. Developments in column technology, inlets, gas flow control, etc., resulted in robust and reliable instrumentation.
In the last decade, attention in separation science shifted towards developments in liquid chromatography and mass spectrometry. Especially the enormous (r)evolution in MS, with hyphenation of single quadrupole, triple quadrupole and time-of-flight instruments to GC (and HPLC), might lead to the impression that a GC instrument becomes only a (too complicated) “inlet” for a mass spectrometer.
Fifty years after the theoretical work by Golay and 30 years after the invention of fused silica capillaries by Dandenau, the role and potential of CGC is sometimes questioned. In pharmaceutical industry, for instance, the selection of a chromatographic technique is often based on unsubstantiated claims such as “insufficient thermal stability of the solutes”, “too long analyses times in GC” and “irreproducible injection techniques”. Consequently HPLC is preferred, even in cases where GC could deliver a faster, better and greener solution.
In this presentation, examples will be given of state-of-the-art GC and GC-MS techniques that can be used for quality control, detection of trace impurities (such as potentially genotoxic impurities in pharmaceuticals) and other typical analyses performed in different application areas.
By proper column selection and sample introduction, the range of solutes that can be analyzed by GC can be extended. In addition, low thermal mass heating can be applied to shorten analysis times or to improve separation in 2D-GC. The application of capillary flow technology, including effluent splitting and Dean switching, can also be used for fast method development, reduction of analysis time and of column/detector contamination.
About the Speaker:
Dr. Frank David received his Ph.D degree in 1986 at the Laboratory of Organic Chemistry of the Universiteit of Gent under the direction Prof. Dr. M. Verzele.
Since October 1986, Frank David has been R&D manager at the Research Institute for Chromatography (RIC) in Kortrijk under the direction of Prof. Dr. Pat Sandra.
Frank David is author of more than 100 scientific papers in different areas of separation science. His expertise includes capillary gas chromatography, supercritical fluid chromatography (SFC), GC-mass spectroscopy (GC-MS), GC-atomic emission detection (GC-AED), liquid chromatography (HPLC), liquid chromatography-mass spectroscopy (LC-MS), multidimensional chromatography (GC-GC, GCxGC, LC-GC) and miniaturization and automation of sample preparation.
Frank David is also consultant for instrument manufactures and for industrial laboratories in environmental, petrochemical, food, pharmaceutical and chemical industries. In this function he has extensive experience in theoretical and practical training courses.
Since September 2004, Frank David is also a visiting professor at the Pfizer Analytical Research Center of the Ghent University, Belgium.
Details:
| Location: | D'ignazio's Towne House |
| Times: | 5:00 PM Executive Committee Meeting 5:45 PM Social "Hour" 6:30 PM Dinner 7:30 PM Presentation |
| Cost: | $30 |
| Dinner Choices: | Parmesan Encrusted Tilapia 8 oz Sirloin Steak Eggplant Parmesan |
NOTICE TO STUDENTS AND FACULTY: Full-time students with valid ID may attend dinner meetings at half-price. Faculty members at colleges and universities are urged to bring one or more students to the meeting. If they do, they also can attend at half-price.