May Meeting Notice

Tuesday, May 17, 2011

Jim Jorgenson: Exploring the Limits of Resolution in Liquid Chromatography and Capillary Electrophoresis

Jim Jorgenson

University of North Carolina at Chapel Hill

Abstract:

Liquid chromatography and capillary electrophoresis are important techniques for chemical analysis of mixtures. While the basic separation mechanisms of chromatography and electrophoresis are different, there are still some interesting parallels between them. In particular, pressure is a primary factor controlling separation efficiency (theoretical plates) in liquid chromatography, while electrical potential is a primary factor controlling separation efficiency in electrophoresis.

In a direct “brute force” approach it is possible to increase the separation power of liquid chromatography through the use of smaller particles of packing material and the application of higher pressures for pumping mobile phase (Ultra-High Pressure Liquid Chromatography). In an analogous manner it is possible to increase the separating power of capillary electrophoresis through the application of higher electrical potentials (Ultra-High Voltage Capillary Electrophoresis).

Alternatively, enhanced separations can be achieved by creating an "endless" separation system. In capillary electrophoresis, this can be accomplished by doing separations in a circular system (Synchronous Cyclic Capillary Electrophoresis) or in a linear system with a counterflow (Flow Counterbalanced Capillary Electrophoresis). Similar improvements can be attained by doing liquid chromatography in a cyclic system (Recycling Chromatography).

About the Speaker:

James Jorgenson was born in Kenosha, Wisconsin in 1952. He received his undergraduate education at Northern Illinois University where he received a B.S. in Chemistry in 1974. Following this he entered graduate school at Indiana University, where he worked in the research group of Professor Milos Novotny, and received a Ph.D. in Chemistry in 1979. His Ph.D. research concerned two principal areas; the study of mammalian pheromones, and the development of new detection schemes for liquid chromatography.

Dr. Jorgenson joined the faculty of the University of North Carolina as an Assistant Professor of Chemistry in 1979. He was promoted to Associate Professor in 1985, Professor in 1987, appointed the Francis P. Venable Professor of Chemistry in 1994, and William Rand Kenan, Jr. Distinguished Professor of Chemistry in 1999. He was Chair of the Chemistry Department from 2000 to 2005.

Among the honors he has received are the American Chemical Society Analytical Division Award in Chemical Instrumentation in 1992, the Martin Medal of the Chromatographic Society in 1992, elected a Fellow of the American Association for the Advancement of Science in 1992, the American Chemical Society Award in Chromatography in 1993, the Golay Medal in 1994, the Eastern Analytical Symposium Award in Separation Science in 1995, the Torben Bergman Medal of the Swedish Chemical Society in 1996, the Anachem Award in 1996, the Dal Nogare Award in 1998, the Esselen Award for Chemistry in the Public Interest in 2004, the Pittsburgh Conference Analytical Chemistry Award in 2005, the American Chemical Society Award in Analytical Chemistry in 2007, elected to the American Academy of Arts and Sciences in 2007, and the Ralph N. Adams Award in Bioanalytical Chemistry (2011).

Professor Jorgenson is one of the originators of capillary electrophoresis, with his first publications on this topic appearing in 1981. His current research interests include ultra-high pressure liquid chromatography, multidimensional separations, microscale separations coupled to mass spectrometry, and the design of detectors for chromatography and capillary electrophoresis.

Details:

Location:	D'ignazio's Towne House
Times:	5:00 PM Executive Committee Meeting 5:45 PM Social "Hour" 6:30 PM Dinner 7:30 PM Presentation
Cost:	$30
Dinner Choices:	Crabcakes Veal Parmesan Eggplant Parmesan

NOTICE TO STUDENTS AND FACULTY: Full-time students with valid ID may attend dinner meetings at half-price. Faculty members at colleges and universities are urged to bring one or more students to the meeting. If they do, they also can attend at half-price.