November Meeting Notice

Thursday, November 19, 2009

Professor Peter J. Schoenmakers: LIQUID CHROMATOGRAPHY: 2D or not 2D?

Professor Peter J. Schoenmakers

Polymer-Analysis Group
Van 't Hoff Institute for Molecular Science (HIMS)
Faculty of Science
University of Amsterdam
Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands

Abstract:

There are two reasons to perform comprehensive two-dimensional liquid chromatography (LCxLC). The first is to increase the number of components that may possibly be separated. The peak capacity of LC systems has been increased significantly by the advances in instrumentation and column technology. Many hundreds of peaks can be accommodated in a single LC run. Patient researchers may even reach a peak capacity of 1000 (in about a day). While impressive, these results are still well short of the most ambitious targets. For example, the human proteome is assumed to contain some 50,000 proteins. The use of LC×LC constitutes a significant step in the right direction. Using this technique a peak capacity of several thousand can be achieved within a reasonable time (one or two hours). The second reason why LC×LC may be advantageous is the possibility to generate structure chromatograms, which can be readily and rigorously interpreted. This is true for samples of polymers, which have a limited sample dimension, implying that only a few characteristics (e.g. molecular weight, end groups) differ between the different molecules in the sample. It may also be true in other situations, such as the oxidative stability of pharmaceutical preparations. In this lecture the potential and practical performance of one-dimensional LC and LC×LC will be compared. Different ways of performing LC×LC will be discussed and we will take a peek into the future. Is LC×LC×LC a realistic option?

About the Speaker:

Peter Schoenmakers obtained a Masters Degree in chemical engineering from the Technical University of Delft, The Netherlands in 1977. After a research project on reversed-phase liquid chromatography that included a year at Northeastern University (Boston, MA, USA) with Professor Barry Karger, he obtained his Ph.D. from Professor Leo de Galan in Delft (1981). After fulfilling his military service, he had a career in industrial R&D, first at Philips (Eindhoven, NL; 1983-1992) and subsequently at Shell (Amsterdam, NL and Houston, TX, USA; 1992-2002). In 1998 he became a part-time professor in Polymer Analysis at the University of Amsterdam. Since 2002 he is a full-time professor. He teaches analytical chemistry to students in the BSc chemistry and MSc analytical sciences programs, as well as to students in forensic science and art conservation. His research interests include analytical separations (chromatography and mass spectrometry) and their applications to large molecules. A specific focus in recent years has been on the theory and application of comprehensive two-dimensional liquid chromatography.
Peter Schoenmakers is active in the organization of several successful symposium series. He is a member of the permanent scientific committee of the HPLC series of conferences and chairman of the symposia on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM) and Hyphenated Techniques in Chromatography (HTC). He has been editor of the Journal of Chromatography A since 2003.
REMEMBER THAT THE REGISTRATION DEADLINE IS EARLIER THAN NORMAL FOR THIS MEETING!
Late Registration till Saturday, Nov. 14: Call or e-mail Sheree Gold
Late Registration on Saturday till the meeting: E-MAIL ONLY

Details:

Location:	Ace Center
Times:	5:00 PM Executive Committee Meeting 5:45 PM Social "Hour" 6:30 PM Dinner 7:30 PM Presentation
Cost:	$30
Dinner Choices:	Buffet

NOTICE TO STUDENTS AND FACULTY: Full-time students with valid ID may attend dinner meetings at half-price. Faculty members at colleges and universities are urged to bring one or more students to the meeting. If they do, they also can attend at half-price.