Printable Meeting FlierMarch Meeting Notice
Tuesday, March 11, 2008
Surfactant-Based Separation Media in HPLC and Capillary Electrophoresis: Recent Advances and Pharmaceutical Applications
Professor Joe P. Foley
Department of Chemistry, Drexel University, Philadelphia, PA
Abstract:
Surfactants have played an important role in many subdisciplines of separation science. In HPLC, their primary use has been as dynamic aggregates known as micelles, and aqueous or predominantly aqueous solutions of micelles have proven to be a useful alternative mobile phase to the conventional hydro-organic mobile phases employed in reversed phase liquid chromatography (RPLC). They have also been employed in a variety of aggregate formats (micelles, microemulsions, vesicles, and liposomes) in capillary and microchip electrophoresis (CE), but as a pseudostationary phase in order to separate neutral or charged compounds with similar or identical electrophoretic mobilities (e.g., enantiomers).
Following a brief introduction, the fundamental aspects of micellar liquid chromatography (MLC) and electrokinetic chromatography (EKC) are summarized, and new research is then discussed. Approaches to improving the efficiency in MLC via optimization of stationary and mobile phase conditions are described. The development and use of novel vesicles and stereoselective microemulsions in EKC is reported for general purpose and chiral separations, respectively.
Applications to be described include (i) the separation of hydrophobic pharmaceuticals in biological samples with no sample pretreatment, (ii) the unique and often synergistic separation of enantiomers via novel chiral microemulsions, and (iii) the rapid in-vitro estimation of drug-membrane permeabilities (high-throughput screening) using synthetic surfactant vesicles.
About the Speaker:
Joe Foley is Professor of Chemistry at Drexel University. He graduated Valedictorian from Centre College with a B.S. in chemistry and chemical physics, received his Ph.D. in Chemistry from the University of Florida, and accepted a 2-year NRC Postdoctoral Fellowship at NIST. While on sabbatical from Drexel (2006-2007) he was Visiting Professor of Chemistry in the Institute of Pharmaceutical Technology at the University of Frankfurt (Germany).
Prof. Foley's research interests are in the fundamental and applied aspects of analytical chemistry and separation science, and he has authored or co-authored over 95 articles, book chapters, and reviews pertaining to pressure- and voltage-driven liquid-phase separations. An ISI Highly-Cited Author, several equations from Prof. Foley's publications have appeared in undergraduate textbooks and/or graduate monographs. Prof. Foley currently serves on the editorial board of Electrophoresis, having previously served on the boards of Analytical Communications, The Analyst, and the Journal of Microcolumn Separations, and on the Scientific Committee of the Frederick Conference on Capillary Electrophoresis.
Prof. Foley has organized and spoken in numerous invited scientific symposia for the American Chemical Society, the Gordon Research Conferences, the Electrophoresis Society, the Pittsburgh Conference, the Eastern Analytical Symposium, and Federation of Analytical Chemistry and Spectroscopy Societies. He is a lifetime member of the Chromatography Forum of the Delaware Valley and resides in Wilmington, DE with his wife and 2 children.
Details:
| Location: | D'ignazio's Towne House |
| Times: | 5:00 PM Executive Committee Meeting 5:45 PM Social "Hour" 6:30 PM Dinner 7:30 PM Presentation |
| Cost: | $30 |
| Dinner Choices: | Chicken Breast with Bread Stuffing Salmon Eggplant Parmesan with Marinara Sauce |
NOTICE TO STUDENTS AND FACULTY: Full-time students with valid ID may attend dinner meetings at half-price. Faculty members at colleges and universities are urged to bring one or more students to the meeting. If they do, they also can attend at half-price.