The Chromatography Forum

of Delaware Valley

Join CFDV and NJCG for a joint evening virtual event focused on compact liquid chromatography!

Registration can be completed below or at the NJCG website: https://www.njcg.org/

Speaker 1:

Jim Grinias, Associate Professor, Rowan University

The Potential for Portable Liquid Chromatography in Chemical Analysis

Abstract:

Trends in miniaturization have revolutionized the consumer electronics industry. Analogous advancements have been observed in analytical chemistry by implementing microfabrication and microfluidic techniques, but traditional laboratory equipment is often still required if chemical separations are integrated into these devices. In this presentation, the use of a completely portable liquid chromatography system that overcomes this barrier will be demonstrated with a number of applications. To achieve portability, this system utilizes small, high-pressure pumps coupled to a cartridge that contains a capillary LC column and on-column LED-UV absorbance detectors. Integrated software that combines system control, data acquisition, and data processing can be accessed by other portable electronic devices. Initial use of the system focused on potency and impurity testing of over-the-counter analgesic drugs. Method development for high-throughput separations of illicit drugs that could be implemented for substance abuse monitoring in point-of-care settings was also conducted. Bench-scale reaction monitoring can be achieved by coupling the system to a simple sampling mechanism. Finally, the exploration of various column types to increase the analytical throughput that can be achieved using this system will be discussed.

Bio:

James Grinias is currently an Associate Professor in the Department of Chemistry & Biochemistry at Rowan University in Glassboro, NJ. His research interests include improving the throughput and efficiency of chromatographic separations and the miniaturization of chemical measurement techniques. He received his Ph.D. from the University of North Carolina at Chapel Hill in 2014 and the moved onto a postdoctoral fellowship at the University of Michigan until the end of 2016. James has received a number of awards for his work to date, including the HPLC 2013 Csaba Horváth Award, the 2020 Young Investigator Award from the Chinese American Chromatography Association, a National Science Foundation CAREER grant, the 2021 American Chemical Society Satinder Ahuja Young Investigator in Separation Science Award, and the 2022 LCGC Emerging Leader in Chromatography Award. He was also named to The Analytical Scientist’s “Top 40 Under 40” Power List in 2018. To date, he has published over 30 articles and given over 80 oral/poster presentations.

Speaker 2:

Charles Goss, Scientic Leader and GSK Fellow in Medicinal Science and Technology, GlaxoSmithKline

ETC Compact HPLC

Abstract:

This presentation will describe the Enabling Technologies Consortium (ETC) Compact HPLC project and illustrate some of the work done at GlaxoSmithKline to support its objectives.

Bio:

Charles Goss is a Scientic Leader and GSK Fellow in Medicinal Science and Technology at GlaxoSmithKline.  He provides analytical chemistry support to cross-functional drug development teams responsible for supplying the active pharmaceutical ingredient and formulated drug products used in pre-clinical and clinical studies.  He serves as a technical resource in several areas such as process monitoring, separation sciences, electrochemistry, microscopy and new analytical technologies.  He received a B.A. in chemistry from Cornell University, a Ph.D. in chemistry from the University of California at Berkeley, and was a post-doctoral fellow in chemistry at the University of North Carolina Chapel Hill.

This event is kindly sponsored by Axcend Corporation.